Answer both of the following discussion questions for your discussion response.

1. Discuss the epidemiology of thalassemia and share evidence-based practice guidelines necessary for chronic management.
2. Sickle-cell anemia has treatment parameters in the chronic state and acute exacerbation. The acute phase requires aggressive hydration and pain medication. What is the physiologic pattern for this problem?

at least 250 words. with reference no older than 5 years and intext citation.